Myeloid-Derived Suppressor Cells Prevent
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چکیده
منابع مشابه
Multiple Low Doses of 5-Fluorouracil Diminishes Immunosuppression by Myeloid Derived Suppressor Cells in Murine Melanoma Model
Background: Melanoma progression and metastasis is suggested to be mediated by increased accumulation of myeloid derived suppressor cells. Various chemotherapeutic drugs such as 5-Fluorouracil in single low concentration have the capacity, at least in part, to reverse tumor progression by reducing myeloid derived suppressor cellsmediated immunosuppression. Objective: To assess whether multiple ...
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Background: Regulatory T Cells (Tregs) and Myeloid-Derived Suppressor Cells (MDSCs) are two main regulatory cells modulating the immune responses in inflammation and cancer. Objective: To investigate and compare Tregs and MDSCs in peptic ulcer and gastric cancer. Methods: Patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (NUD, n=22), peptic ulcer disease...
متن کاملImmune effects of 5-fluorouracil
Cytotoxic anticancer drugs can promote antitumor immune responses. The anticancer activity of 5-fluorouracil (5FU) relies on the restoration of T-cell immunity following the elimination of myeloid-derived suppressor cells (MDSCs). We have recently discovered that the 5FU-driven activation of the NLRP3 inflammasome in MDSCs promotes tumor angiogenesis by eliciting TH17 responses that compromise ...
متن کاملMyeloid-Derived Suppressor Cells in Animal Transplantation Models
Submit Manuscript | http://medcraveonline.com granulocytes, dendritic cells (DC) and immature myeloid cells (IMC) [1-3]. There are many researches on tumor MDSCs and negative effect on immune system [4,5]. Because of the negative regulation of immune response through different ways, MDSCs related researches are performed by transplant immunologists [6,7]. Many research find that MDSCs can preve...
متن کاملMyeloid-Derived Suppressor Cells in Animal Transplantation Models
Submit Manuscript | http://medcraveonline.com granulocytes, dendritic cells (DC) and immature myeloid cells (IMC) [1-3]. There are many researches on tumor MDSCs and negative effect on immune system [4,5]. Because of the negative regulation of immune response through different ways, MDSCs related researches are performed by transplant immunologists [6,7]. Many research find that MDSCs can preve...
متن کاملTwist and miR-34a Are Involved in the Generation of Tumor-Educated Myeloid-Derived Suppressor Cells
Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells in the tumor microenvironment, contributing to tumor immunological escapes. Many studies have demonstrated that multiple factors could induce myeloid precursor cells into myeloid-derived suppressor cells, not dendritic cells. In our study, we found that tumor supernatants could ...
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